You can publish your book online for free in a few minutes. Intravenous admixtures preparation and infusion guidelines. Propofol is chemically described as 2,6diisopropylphenol. To search compatibility information from the trissels 2 clinical pharmaceutics database by lawrence a. Lets leave the cook book recipes to our nurse colleagues. Slow iv can cause pain, not usually irritant if given extravascularly where is propofol metabolized.
Jan 18, 2017 strict aseptic technique must always be maintained during handling. It is also used for status epilepticus if other medications have not worked. In this study, 5102040 mg lidocaine was added to 20. American college of critical care medicine recommends use of a central vein for administration in an icu setting. Use of propofol in patients with haemodynamic instability requires prior consultation with the qas oncall medical officer.
Propofol injectable emulsionis a singleuse parenteral product which contains benzyl alcohol 1. Propofol infusion syndrome bja education oxford academic. Infuse the propofol through a tpiece connected immediately proximal to the iv catheter to minimize dead space. Physicochemical compatibility of propofollidocaine. In addition to updating drug interactions, precautions, alerts, and patient teaching instructions for all existing iv drugs. Its an anesthetic used to put people to sleep before surgery. Intravenous compatibility chart drug information for the. Propofol compatibility with other intravenous drug productstwo new methods of evaluating iv emulsion compatibility. Possible drugsolution selections will be displayed as you continue to type. Soybean fat emulsion is used as a vehicle for propofol. Intravenous iv preparation and infusion guidelines globalrph. Items are typically shipped in a plastic bag, in a cardboard cradle, in a manila envelope. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for this dosing guide is obtained.
Kennedy, bpharm, phd division of anesthesia and intensive care, the prince of wales hospital, randwick, new south wales, australia, and the. No effect or incompatibility with nacetylcysteine or amino acid solutions was detected. Helping healthcare professionals by providing the most trusted drug and clinical information available, delivered across multiple platforms, and easily integrated into daily workflow. Propofol compatibility with other intravenous drug products. When i asked him about it, he said none of my patients will receive diprivan through a peripheral line. Intravenous injection of a therapeutic dose of propofol produces hypnosis rapidly. Propofol and remifentanil often need to be coadministered via the same intravenous catheter line, which predisposes to potential compatibility. Compatibility of propofol, fentanyl, and vecuronium mixtures. Propofol injectable emulsion should not be coadministered through the same iv catheter with blood or plasma because compatibility has not been established. Propofol is an intravenous iv sedativehypnotic agent that can be used for initiation and maintenance of monitored anesthesia care sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit sedation of intubated, mechanically ventilated patients. Propofol is an intravenous anesthetic that is used for procedural sedation, during.
Incompatibilities are based on meeting any of the following criteria. Oct 17, 2006 a new critical care md in our unit ordered diprivan per short term sedation protocol only through a central line. Isert, mb, bs, fanzca, doris lee, bsc,f daya naidoo, mbchb, frcpa, md,f melanie l. Propofol compatibility with other intravenous drug. Strict aseptic technique must always be maintained during handling.
The essential information you need to safely administer more than 400 intravenous drugs. In vitro tests have shown that aggregates of the globular component of the emulsion vehicle have occurred with bloodplasmaserum from humans and animals. All cannulae and iv lines must be flushed thoroughly with sodium chloride 0. Critical care intravenous drug administration guide. Diprivan propofol dosing, indications, interactions. Strict aseptic technique must be maintained in handling, although a preservative has been added. Following a single iv injection, onset as determined by time to unconsciousness i. Iv drug compatibility chart g ganciclovir sodium gemcitabine hydrochloride gemtuzumab ozogamicin gentamicin sulfate granisetron hydrochloride. Caspofungin acetate, ciproploxacin, enalaprilat, fluconazole, levofloxacin, meropenem, propofol, vasopressin, and zidovudine.
Its given by iv and should only be administered by. Propofol, valproic acid, phenytoin, theophylline, methylprednisolone and furosemide were also incompatible, whereas ketamine, sufentanil, midazolam, morphine, piritramide, nicardipine, urapidil, dopamine, dobutamine and adrenaline were compatible. This book is distributed under the terms of the creative commons. Pdf linkpdf american association of criticalcare nurses. Concurrent simvastatin therapy diltiazem dose should not exceed 240 mgday and simvastatin dose should not exceed 10 mgday. Intravenous compatibility chart free html5 flip book. Propofol is the generic name for diprivan, which is a prescription, injectable drug. The safe dose of propofol infusion for sedation in intensive care is considered to be 14 mg kg. It has low organ toxicity and is very compatible with a wide range of other.
Propofol fda prescribing information, side effects and uses. Propofol is slightly soluble in water and, thus, is formulated in a white, oilinwater. Induction of anesthesia with propofol may be associated with pain on injection, apnea, and a reduction in arterial blood pressure bp. Using the formula provided on the iv dosage calulator page, dose ordered 2. Increase dose in patients with chronic alcoholism fassoulaki, 1993. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. Diprivan is an intravenous general anesthetic and sedation drug for use in the induction. The decline in propofol concentrations following a bolus dose or following the termination of an infusion can be described by a three compartment open model with very rapid distribution halflife 2 4 minutes, rapid elimination halflife 30 60 minutes, and a slower final phase, representative of redistribution of propofol from poorly. Administered iv only, resulting in complete absorption. If your patient is too deep, turn off the propofol for a minute or two.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. Intravenous compatibility chartcisatracurium nimbex dexmedetomidine precedex dobutamineacyclovir acyclovir. Propofol is an intravenous iv sedativehypnotic agent that can be used for initiation and maintenance of monitored anesthesia care sedation, combined sedation and regional anesthesia, induction of general anesthesia, maintenance of general anesthesia, and intensive care unit sedation of intubated, mechanically ventilated patients propofol is available under the following different brand. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Propofol is a prescription medication used for sedation and anesthesia. Diprivan and generic propofol are compatible with the following intravenous fluids when administered through a ytype infusion set. Propofol is a strong anesthetic thats used for surgery, some medical exams, and for sedation for people on ventilators never as a sleep aid. These work by slowing activity in the brain to prevent pain and allow sleep. Propofol, marketed as diprivan among other names, is a shortacting medication that results in a decreased level of consciousness and a lack of memory for events. All us items are shipped with delivery confirmation, if you require this, please let me know. When increased intracranial pressure is suspected, hyperventilation and hypocarbia should accompany propofol administration. A new critical care md in our unit ordered diprivan per short term sedation protocol only through a central line.
Book is in very good shape, no tears, scribbles or underlining, a little general wear, from a smokefree environment. Propofol diprivan side effects, dosage, interactions drugs. Click on trissels iv compatibility to open the module. Propofol diprivan side effects, dosage, interactions.
In addition to updating drug interactions, precautions, alerts, and patient teaching. When provided at an infusion rate exceeding 20 ml hr, the caloric value of the propofol in combination with feeds can lead to significant overfeeding. We are also reporting the results of compatibility studies for pantoprazole in admixture with 90 parenteral products including. Diprivan 1% summary of product characteristics smpc. Do not administer through the same iv catheter with blood or plasma. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. To reduce pain associated with injection, use larger veins of forearm or antecubital fossa. Induction andor maintenance of anesthesia as the sedative and hypnotic component of balanced anesthesia benzodiazepines, anticholinergic agents, depolarizing and nondepolarizing skeletal muscle relaxants, opiate analgesics, inhalation andor regional anesthetic or total iv anesthesia balanced anesthesia. Find information on propofol diprivan in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action. Diprivan propofol injectable emulsion paperback january 1, 1997 see all formats and editions hide other formats and editions. Trissel, begin by typing the desired drug or solution name into the appropriate search box.
Overfeeding is associated with hyperglycemia, fatty liver, hypertryglyceridemia, and excess co. In addition to the above mentioned studies, masaki et al. Emulsion stability of different intravenous propofol formulations in. Intravenous compatibility chart free html5 flip book maker. Stability and compatibility of vancomycin for administration. Solubilized in a soybean emulsion, propofol is one of a series of sterically hindered phenols that exhibit anesthetic activity. Elsevier compatibility of propofol, fentanyl, and vecuronium mixtures designed for potential use in anesthesia and patient transport peter r. Each monograph contains stability data, administration guidelines, and methods of preparation. The infusion can be titrated to blood pressure and heart rate. Atracurium iv loading dose, then infusion with pump loading dose 300600 microgramskg then 300 600 microgramskghour usually given neat. Physicochemical compatibility of propofollidocaine mixture. If the infusion rate is not turned down over time the patient will be overdosed. Propofol side effects, uses, dosage, overdose, pregnancy.
Iv geriatric patients, debilitated patients, or asa iiiiv patients. Start administration promptly and complete within 12 hours after opening the vials or syringes. Every patient is different and every patient deserves a thoughtful plan by a consultant anesthesiologist. Compatibility of propofol, fentanyl, and vecuronium. Calcium chloride ampicillin ampicillin yes calcium. Diprivan 1% summary of product characteristics smpc emc. By slow intravenous injection, or by intravenous infusion. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Iv geriatric patients, debilitated patients, or asa iii iv patients.
Intravenous injection of a therapeutic dose of propofol induces anesthesia, with minimal excitation, usually within 40 seconds from the start of injection the time for one armbrain circulation. Diprivan is an intravenous general anesthetic and sedation drug for use in the induction and maintenance of anesthesia or sedation. Trissel, fashp, 2010, american society of healthsystem pharmacists. And given that the drug insert does explicitly state that propofol is compatible with d5, lr and some other ivf, but not nss, it is unlikely that your policy is going to change. Po adults 40 twice daily initially when added to regimen, v dose of other antihypertensives by 50%. Information in this booklet should be used as a guide only.
Intravenous compatibility chart acyclovir acyclovir. Propofol is chemically described as 2,6diisopropylphenol and has a molecular weight of 178. When combined with propofol, one suggested regimen consists of 0. This medication is available in an injectable form to be given directly into a vein iv by a healthcare professional. Diprivan propofol dose, indications, adverse effects. Im iv adults 2040 mg, may repeat in 12 hr and by 20 mg every 12 hr until response is obtained, maintenance dose may be given every 612 hr. Mar 05, 2020 propofol injectable emulsion should not be coadministered through the same iv catheter with blood or plasma because compatibility has not been established. If you have questions, see your departments pharmacist or call pharmacy and ask. Propofol belongs to a group of drugs called general anesthetics.
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